Planar cell polarity in organ formation
File(s)
Author(s)
Henderson, Deborah J
Long, David A
Dean, Charlotte H
Type
Journal Article
Abstract
The planar cell polarity (PCP) pathway controls a variety of morphological events across many species. During embryonic development, the PCP pathway regulates coordinated behaviour of groups of cells to direct morphogenetic processes such as convergent extension and collective cell migration. In this review we discuss the increasingly prominent role of the PCP pathway in organogenesis, focusing on the lungs, kidneys and heart. We also highlight emerging evidence that PCP gene mutations are associated with adult diseases.
Date Issued
2018-12-01
Date Acceptance
2018-06-21
Citation
Current Opinion in Cell Biology, 2018, 55, pp.96-103
ISSN
0955-0674
Start Page
96
End Page
103
Journal / Book Title
Current Opinion in Cell Biology
Volume
55
Copyright Statement
© 2018 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Royal Brompton & Harefield NHS Foundation Trust
Royal Brompton & Harefield NHS Foundation Trust
Grant Number
B1064
B1064
Subjects
0601 Biochemistry And Cell Biology
Developmental Biology
Notes
publisher: Elsevier articletitle: Planar cell polarity in organ formation journaltitle: Current Opinion in Cell Biology articlelink: https://doi.org/10.1016/j.ceb.2018.06.011 content_type: article copyright: © 2018 Elsevier Ltd. All rights reserved.
Publication Status
Published
Article Number
C
Date Publish Online
2018-07-14