Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG
File(s)
Published version
Accepted version
Author(s)
Shah, AV
Birdsey, GM
Randi, AM
Type
Journal Article
Abstract
Over the last few years, the ETS transcription factor ERG has emerged as a major regulator of
endothelial function. Multiple studies have shown that ERG plays a crucial role in promoting
angiogenesis and vascular stability during development and after birth. In the mature
vasculature ERG also functions to maintain endothelial homeostasis, by transactivating
genes involved in key endothelial functions, whilst repressing expression of pro‐
inflammatory genes. Its homeostatic role is lineage-specific, since ectopic expression of ERG
in non-endothelial tissues such as prostate is detrimental and contributes to oncogenesis.
This review summarises the main roles and pathways controlled by ERG in the vascular
endothelium, its transcriptional targets and its functional partners and the emerging
evidence on the pathways regulating ERG’s activity and expression.
endothelial function. Multiple studies have shown that ERG plays a crucial role in promoting
angiogenesis and vascular stability during development and after birth. In the mature
vasculature ERG also functions to maintain endothelial homeostasis, by transactivating
genes involved in key endothelial functions, whilst repressing expression of pro‐
inflammatory genes. Its homeostatic role is lineage-specific, since ectopic expression of ERG
in non-endothelial tissues such as prostate is detrimental and contributes to oncogenesis.
This review summarises the main roles and pathways controlled by ERG in the vascular
endothelium, its transcriptional targets and its functional partners and the emerging
evidence on the pathways regulating ERG’s activity and expression.
Date Issued
2016-05-18
Date Acceptance
2016-04-18
Citation
Vascular Pharmacology, 2016, 86, pp.3-13
ISSN
1879-3649
Publisher
Elsevier
Start Page
3
End Page
13
Journal / Book Title
Vascular Pharmacology
Volume
86
Copyright Statement
© 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
License URL
Sponsor
British Heart Foundation
Grant Number
RG/11/17/29256
Subjects
Angiogenesis
ETS transcription factors
Endothelial homeostasis
Gene transcription
Vascular development
Cardiovascular System & Hematology
1115 Pharmacology And Pharmaceutical Sciences
Publication Status
Published