NF-κB: blending metabolism, immunity, and inflammation
File(s)Trends Immunol 2022.pdf (1.43 MB)
Article in Press
Author(s)
Type
Journal Article
Abstract
The procurement and management of nutrients and ability to fight infections are fundamental requirements for survival. These defense responses are bioenergetically costly, requiring the immune system to balance protection against pathogens with the need to maintain metabolic homeostasis. NF-κB transcription factors are central regulators of immunity and inflammation. Over the last two decades, these factors have emerged as a pivotal node coordinating the immune and metabolic systems in physiology and the etiopathogenesis of major threats to human health, including cancer, autoimmunity, chronic inflammation, and others. In this review, we discuss recent advances in understanding how NF-κB-dependent metabolic programs control inflammation, metabolism, and immunity and how improved knowledge of them may lead to better diagnostics and therapeutics for widespread human diseases.
Date Issued
2022-09-01
Online Publication Date
2022-09-16T09:41:34Z
Date Acceptance
2022-07-12
ISSN
0167-5699
Publisher
Cell Press
Start Page
757
End Page
775
Journal / Book Title
Trends in Immunology
Volume
43
Issue
9
Copyright Statement
© 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URI
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/35965153
S1471-4906(22)00141-7
Subjects
Autoimmunity
Homeostasis
Humans
Inflammation
NF-kappa B
Neoplasms
Humans
Neoplasms
Inflammation
NF-kappa B
Autoimmunity
Homeostasis
Autoimmunity
Homeostasis
Humans
Inflammation
NF-kappa B
Neoplasms
Immunology
1107 Immunology
Publication Status
Published
Country
England
Date Publish Online
2022-08-11