Epstein-Barr viruses deficient in EBER RNAs give higher LMP2 RNA expression in lymphoblastoid cell lines and efficiently establish persistent infection in humanized mice.
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Functions of EBER RNAs were tested in lymphoblastoid cell lines containing EBER mutants of Epstein-Barr Virus (EBV). Binding of EBER1 to RPL22 was confirmed. Deletion of EBER1 or EBER2 correlated with increased cytoplasmic EBV LMP2 RNA and with small effects on specific cellular miRNA levels but protein levels of LMP1 and LMP2A were not affected. Wild type and EBER deletion EBV had approximately equal ability to infect immunodeficient mice reconstituted with a human haematopoietic system.
Date Issued
2015-09-02
Date Acceptance
2015-09-02
Citation
Journal of Virology, 2015, 89 (22), pp.1171-11714
ISSN
1098-5514
Publisher
American Society for Microbiology
Start Page
1171
End Page
11714
Journal / Book Title
Journal of Virology
Volume
89
Issue
22
Copyright Statement
© 2015, American Society for Microbiology. All Rights Reserved.
The authors have paid a fee to allow immediate free access to this article.
The authors have paid a fee to allow immediate free access to this article.
License URL
Identifier
PII: JVI.01873-15
Publication Status
Accepted