An automated system for fast transfer and injection of hyperpolarized solutions
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Published version
OA Location
Author(s)
Type
Journal Article
Abstract
Dissolution dynamic nuclear polarization (dDNP) has become a hyperpolarization method of choice for enhancing nuclear magnetic resonance (NMR) signals. Nuclear spins are polarized in solid frozen samples (in a so-called polarizer) that are subsequently dissolved and transferred to an NMR spectrometer for high sensitivity detection. One of the critical challenges of dDNP is that it requires both a fast transfer to limit nuclear spin relaxation losses as well as stability to guarantee high resolution (no bubbles nor turbulences). Here we describe the design, construction and performances of such a transfer and injection system, that features a 5 m/s speed and sub-Hz spectral resolution upon arrival at the detection spot. We demonstrate the use of such a system for inter-magnet distances of up to 10 m.
Date Issued
2021-12-01
Date Acceptance
2021-07-23
Citation
Journal of Magnetic Resonance Open, 2021, 8-9
ISSN
2666-4410
Publisher
Elsevier
Journal / Book Title
Journal of Magnetic Resonance Open
Volume
8-9
Copyright Statement
© 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/)
Identifier
10.1016/j.jmro.2021.100017
Subjects
Biochemical Research Methods
Biochemistry & Molecular Biology
dDNP
Dissolution
DISSOLUTION
DYNAMIC NUCLEAR-POLARIZATION
FLOW
Hyperpolarization
Instrumentation
Life Sciences & Biomedicine
NMR
NMR-SPECTROSCOPY
Physical Sciences
Physics
Physics, Atomic, Molecular & Chemical
Science & Technology
Spectroscopy
Technology
Transfer
Publication Status
Published
Article Number
ARTN 100017
Date Publish Online
2021-08-01