Repository logo
  • Log In
    Log in via Symplectic to deposit your publication(s).
Repository logo
  • Communities & Collections
  • Research Outputs
  • Statistics
  • Log In
    Log in via Symplectic to deposit your publication(s).
  1. Home
  2. Faculty of Natural Sciences
  3. Chemistry
  4. Chemistry
  5. An automated system for fast transfer and injection of hyperpolarized solutions
 
  • Details
An automated system for fast transfer and injection of hyperpolarized solutions
File(s)
1-s2.0-S266644102100008X-main.pdf (5.25 MB)
Published version
OA Location
http://dx.doi.org/10.1016/j.jmro.2021.100017
Author(s)
Ceillier, Morgan
Cala, Olivier
El Darai, Theo
Cousin, Samuel F
Stern, Quentin
more
Type
Journal Article
Abstract
Dissolution dynamic nuclear polarization (dDNP) has become a hyperpolarization method of choice for enhancing nuclear magnetic resonance (NMR) signals. Nuclear spins are polarized in solid frozen samples (in a so-called polarizer) that are subsequently dissolved and transferred to an NMR spectrometer for high sensitivity detection. One of the critical challenges of dDNP is that it requires both a fast transfer to limit nuclear spin relaxation losses as well as stability to guarantee high resolution (no bubbles nor turbulences). Here we describe the design, construction and performances of such a transfer and injection system, that features a 5 m/s speed and sub-Hz spectral resolution upon arrival at the detection spot. We demonstrate the use of such a system for inter-magnet distances of up to 10 m.
Date Issued
2021-12-01
Date Acceptance
2021-07-23
Citation
Journal of Magnetic Resonance Open, 2021, 8-9
URI
https://hdl.handle.net/10044/1/118747
URL
https://doi.org/10.1016/j.jmro.2021.100017
DOI
https://www.dx.doi.org/10.1016/j.jmro.2021.100017
ISSN
2666-4410
Publisher
Elsevier
Journal / Book Title
Journal of Magnetic Resonance Open
Volume
8-9
Copyright Statement
© 2021 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/)
License URL
https://creativecommons.org/licenses/by-nc-nd/4.0/
Identifier
10.1016/j.jmro.2021.100017
Subjects
Biochemical Research Methods
Biochemistry & Molecular Biology
dDNP
Dissolution
DISSOLUTION
DYNAMIC NUCLEAR-POLARIZATION
FLOW
Hyperpolarization
Instrumentation
Life Sciences & Biomedicine
NMR
NMR-SPECTROSCOPY
Physical Sciences
Physics
Physics, Atomic, Molecular & Chemical
Science & Technology
Spectroscopy
Technology
Transfer
Publication Status
Published
Article Number
ARTN 100017
Date Publish Online
2021-08-01
About
Spiral Depositing with Spiral Publishing with Spiral Symplectic
Contact us
Open access team Report an issue
Other Services
Scholarly Communications Library Services
logo

Imperial College London

South Kensington Campus

London SW7 2AZ, UK

tel: +44 (0)20 7589 5111

Accessibility Modern slavery statement Cookie Policy

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science

  • Cookie settings
  • Privacy policy
  • End User Agreement
  • Send Feedback