Slow wave sleep and accelerated forgetting
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Published version
Author(s)
Type
Journal Article
Abstract
We investigated whether the benefit of slow wave sleep (SWS) for memory consolidation typically observed in healthy individuals is disrupted in people with accelerated long-term forgetting (ALF) due to epilepsy. SWS is thought to play an active role in declarative memory in healthy individuals and, furthermore, electrographic epileptiform activity is often more prevalent during SWS than during wakefulness or other sleep stages. We studied the relationship between SWS and the benefit of sleep for memory retention using a word-pair associates task. In both the ALF and the healthy control groups, sleep conferred a memory benefit. However, the relationship between the amount of SWS and sleep-related memory benefits differed significantly between the groups. In healthy participants, the amount of SWS correlated positively with sleep-related memory benefits. In stark contrast, the more SWS, the smaller the sleep-related memory benefit in the ALF group. Therefore, contrary to its role in healthy people, SWS-associated brain activity appears to be deleterious for memory in patients with ALF.
Date Issued
2016-11-01
Date Acceptance
2016-08-29
ISSN
0010-9452
Publisher
Elsevier
Start Page
80
End Page
89
Journal / Book Title
Cortex
Volume
84
Copyright Statement
© 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Identifier
https://www.sciencedirect.com/science/article/pii/S0010945216302374?via%3Dihub
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000387835900007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Social Sciences
Life Sciences & Biomedicine
Behavioral Sciences
Neurosciences
Psychology, Experimental
Neurosciences & Neurology
Psychology
Accelerated long-term forgetting
Transient epileptic amnesia
Memory
Consolidation
Slow wave sleep
TRANSIENT EPILEPTIC AMNESIA
MEDIAL TEMPORAL-LOBE
LATE NOCTURNAL SLEEP
DECLARATIVE MEMORY
RECOGNITION MEMORY
DEPENDENT MEMORY
CONSOLIDATION
MODEL
HIPPOCAMPUS
CORTISOL
Accelerated long-term forgetting
Consolidation
Memory
Slow wave sleep
Transient epileptic amnesia
Adult
Epilepsy
Female
Humans
Male
Memory
Mental Recall
Neuropsychological Tests
Sleep
Wakefulness
Humans
Epilepsy
Memory
Mental Recall
Wakefulness
Sleep
Neuropsychological Tests
Adult
Female
Male
Science & Technology
Social Sciences
Life Sciences & Biomedicine
Behavioral Sciences
Neurosciences
Psychology, Experimental
Neurosciences & Neurology
Psychology
Accelerated long-term forgetting
Transient epileptic amnesia
Memory
Consolidation
Slow wave sleep
TRANSIENT EPILEPTIC AMNESIA
MEDIAL TEMPORAL-LOBE
LATE NOCTURNAL SLEEP
DECLARATIVE MEMORY
RECOGNITION MEMORY
DEPENDENT MEMORY
CONSOLIDATION
MODEL
HIPPOCAMPUS
CORTISOL
Experimental Psychology
1109 Neurosciences
1701 Psychology
1702 Cognitive Sciences
Publication Status
Published
OA Location
https://www.sciencedirect.com/science/article/pii/S0010945216302374
Date Publish Online
2016-09-12