While the focus of industry was once to cover people’s needs, it is now imperative to address how to minimize or even stop generating waste, either by decreasing the amount produced or by recycling and reusing it in the same or another synthetic flow. The closed-loop strategy has gained ground in the context of global resource depletion. In this regard, renewable and sustainable processes are required to benefit both the industrial economy and environment. Here we discuss several aspects related to the circular economy, and how this economic system correlates to green chemistry and its application to the peptide science field.