Therapeutic and protective efficacy of a dengue antibody against Zika infection in Rhesus monkeys
File(s)Abbink et al (2018) Nat Med.pdf (63.48 KB) Abbink et al (2018) Nat Med - Suppl.pdf (281.74 KB)
Accepted version
Supporting information
Author(s)
Type
Journal Article
Abstract
Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV) endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potent ly cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV.
Date Issued
2018-06-04
Online Publication Date
2018-12-04T07:00:18Z
Date Acceptance
2018-03-29
ISSN
1078-8956
Publisher
Nature Publishing Group
Start Page
721
End Page
723
Journal / Book Title
Nature Medicine
Volume
24
Copyright Statement
© 2018 Nature America Inc., part of Springer Nature. All rights reserved.
Source Database
manual-entry
Sponsor
Medical Research Council (MRC)
Wellcome Trust
Grant Number
MR/N012658/1
203224/Z/16/Z
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Cell Biology
Medicine, Research & Experimental
Research & Experimental Medicine
VIRUS-INFECTION
CROSS-REACTIVITY
VACCINE
POTENT
ENHANCEMENT
CHALLENGE
11 Medical And Health Sciences
Immunology
Publication Status
Published