Guidelines for minimal information on cellular senescence experimentation in vivo
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Author(s)
Type
Journal Article
Abstract
Cellular senescence is a cell fate triggered in response to stress and is characterized by stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging from tissue repair to chronic disease. The development of new tools to study senescence in vivo has paved the way for uncovering its physiological and pathological roles and testing senescent cells as a therapeutic target. However, the lack of specific and broadly applicable markers makes it difficult to identify and characterize senescent cells in tissues and living organisms. To address this, we provide practical guidelines called “minimum information for cellular senescence experimentation in vivo” (MICSE). It presents an overview of senescence markers in rodent tissues, transgenic models, non-mammalian systems, human tissues, and tumors and their use in the identification and specification of senescent cells. These guidelines provide a uniform, state-of-the-art, and accessible toolset to improve our understanding of cellular senescence in vivo.
Date Issued
2024-08-08
Date Acceptance
2024-06-02
ISSN
0092-8674
Publisher
Elsevier
Start Page
4150
End Page
4175
Journal / Book Title
Cell
Volume
187
Issue
16
Copyright Statement
© 2024 The Authors. Published by Elsevier Inc.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Identifier
https://www.cell.com/cell/fulltext/S0092-8674(24)00640-8
Publication Status
Published
Date Publish Online
2024-08-08