Advances in solid-phase peptide synthesis in aqueous media (ASPPS)
File(s)
Published version
Author(s)
Albericio, Fernando
Jaradat, Da'san MM
Al Musaimi, Othman
Type
Journal Article
Abstract
Peptides are gaining ground in the pharmaceutical arena, with a total of 22 approvals over the last six years. These molecules are also present in antibody-drug conjugate constructs as linkers or payloads, or both. Solid-phase peptide synthesis (SPPS) is the method of choice for peptide synthesis. The introduction of the automatic synthesizer has facilitated this methodology and helped reduce the amounts of solvents needed. However, there are still concerns regarding the amounts, as well as the safety profiles, of the solvents involved in SPPS. Here we discuss work addressing the use of water as the greenest alternative to the common non-green solvents employed in various steps of the SPPS methodology. Various technologies were introduced which enabled the synthesis in aqueous media of di- and up to decapeptide with satisfactory yields and purities
Date Acceptance
2022-08-02
Citation
Green Chemistry, 24
ISSN
1463-9262
Publisher
Royal Society of Chemistry (RSC)
Journal / Book Title
Green Chemistry
Volume
24
Copyright Statement
©2022 The Author(s). Open Access Article. Published on 06 August 2022. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
License URL
Identifier
https://pubs.rsc.org/en/Content/ArticleLanding/2022/GC/D2GC02319A
Subjects
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Green & Sustainable Science & Technology
Chemistry
Science & Technology - Other Topics
N-PROTECTING GROUP
GAMMA-VALEROLACTONE GVL
WATER-BASED SYNTHESIS
COUPLING REAGENTS
AMINO-ACIDS
GREEN SOLVENTS
ACTIVE ESTERS
SUPPORTS
RESIN
TETRAFLUOROBORATE
Organic Chemistry
03 Chemical Sciences
Publication Status
Published online
Date Publish Online
2022-08-06