It is widely acknowledged that the drivers for energy consumption in the residential sector are ambient temperature, energy demand, population density, and socio-economic conditions. However, there are no studies in the literature assessing the temporal and spatial distribution of these drivers for a region or country. The decision-making process of the energy transition will be enhanced by using geospatial-resolved and temporal-explicit energy consumption drivers. This study estimates the climatic, end-use demands, and socio-economic drivers of energy consumption in the residential sector of Ecuador at a high spatio-temporal resolution between 2010 and 2020. This research uses publicly available datasets to calculate seven energy consumption drivers in the residential sector of Ecuador: (1) calibrated gridded population density at 1 km2 resolution; (2) validated gridded space heating demand at 1 km2 resolution; (3) validated gridded space cooling demand at 1 km2 resolution; (4) validated gridded water heating demand at 1 km2 resolution; (5) calibrated gridded gross domestic product at 1 km2 resolution; (6) calibrated gridded gross domestic product per capita at 1 km2 resolution; and (7) calibrated regional human development index, at city level. Disaggregation of the drivers at a high spatial resolution for the entire country in a range of 10 years was considered. The final high-1 km2 resolution results can be used for the evaluation of different energy policies in terms of long-term planning and in techno-economic modelling of energy systems and decarbonisation pathways.