CF fungal disease in the age of CFTR modulators
File(s)
Published version
Author(s)
Bercusson, Amelia
Jarvis, George
Shah, Anand
Type
Journal Article
Abstract
Fungi are increasingly recognised to have a significant role in the progression of lung disease in Cystic fibrosis with Aspergillus fumigatus the most common fungus isolated during respiratory sampling. The emergence of novel CFTR modulators has, however, significantly changed the outlook of disease progression in CF. In this review we discuss what impact novel CFTR modulators will have on fungal lung disease and its management in CF. We discuss how CFTR modulators affect antifungal innate immunity and consider the impact of Ivacaftor on fungal disease in individuals with gating mutations. We further review the increasing complication of drug–drug interactions with concurrent use of azole antifungal medication and highlight key unknowns that require addressing to fully understand the impact of CFTR modulators on fungal disease.
Date Issued
2021-04-04
Date Acceptance
2021-03-03
Citation
Mycopathologia, 2021, 186 (5), pp.1-10
ISSN
0301-486X
Publisher
Springer
Start Page
1
End Page
10
Journal / Book Title
Mycopathologia
Volume
186
Issue
5
Copyright Statement
© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Sponsor
Cystic Fibrosis Trust
Medical Research Council (MRC)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000636627600001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
VIA 081
MR/T005572/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Mycology
Cystic fibrosis
Aspergillus fumigatus
Fungi
Antifungal
Publication Status
Published online
Date Publish Online
2021-04-04