Bronchial artery delivery of viral vectors for gene delivery in cystic fibrosis; superior to airway delivery?
Author(s)
Bakhai A
Sheridan DJ
Coutelle C
Type
Journal Article
Abstract
Background Attempts at gene therapy for the pulmonary manifestations of Cystic Fibrosis have relied mainly on airway delivery. However the efficiency of gene transfer and expression in the airway epithelia has not reached therapeutic levels. Access to epithelial cells is not homogenous for a number of reasons and the submucosal glands cannot be reached via the airways. Presentation We propose to inject gene delivery vectors directly into bronchial arteries combined with pre-delivery of vascular endothelial growth factor to increase vascular endothelial permeability and post-delivery flow reduction by balloon occlusion. Thus it may be possible to reach mucous secreting cells of the bronchial luminal epithelium and the submucosal glands in an increased and homogenous fashion. Testing This combination of techniques to the best of our knowledge has not previously been investigated, and may enable us to overcome some of the current limitations to gene therapy for Cystic Fibrosis.
Date Issued
2002-04-03
Online Publication Date
2002-04-03
2018-10-05T10:57:09Z
Date Acceptance
2002-04-03
ISSN
1471-2466
Publisher
BioMed Central
Journal / Book Title
BMC Pulmonary Medicine
Volume
2
Issue
1
Copyright Statement
© 2002 Bakhai et al; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any purpose, provided
this notice is preserved along with the article's original URL.
this notice is preserved along with the article's original URL.
Source Database
pubmed
Subjects
1102 Cardiovascular Medicine And Haematology
Respiratory System
Edition
1
Article Number
2
Date Publish Online
2002-04-03