microRNAs: novel regulators of the TGF- pathway in pancreatic ductal adenocarcinoma
File(s)
Author(s)
Ottaviani, S
Castellano, Leandro
Type
Journal Article
Abstract
We identified that transforming growth factor-β (TGF-β) induces long non-coding RNA (lncRNA) MIR100HG along with its host microRNAs (miRNAs) miR-100 and miR-125b, to regulate its response in pancreatic ductal adenocarcinoma (PDAC). Importantly let-7a, despite originating from MIR100HG, remains unchanged because post-transcriptionally repressed by lin-28 homolog B (LIN28B). A novel method for global miRNA-target discovery identified that miR-100/125b regulates crucial PDAC pathways.
Date Issued
2018-08-13
Date Acceptance
2018-07-07
Citation
Molecular & Cellular Oncology, 2018, 5 (6), pp.1-3
URI
URL
DOI
ISSN
2372-3556
Publisher
Taylor & Francis
Start Page
1
End Page
3
Journal / Book Title
Molecular & Cellular Oncology
Volume
5
Issue
6
Copyright Statement
© 2018 Taylor & Francis. This is an Accepted Manuscript of an article published by Taylor & Francis in Molecular and Cellular Oncology on 13 August 2018, available online: https://doi.org/10.1080/23723556.2018.1499066
Sponsor
Pancreatic Cancer UK
Imperial College Trust
Identifier
https://www.tandfonline.com/doi/full/10.1080/23723556.2018.1499066
Grant Number
N/A
N/A
Subjects
Science & Technology
Life Sciences & Biomedicine
Oncology
TGF-beta
microRNAs
miR-100
miR-125b
let-7
EMT
CSC
stemness
metastasis
PDAC
CANCER
TUMORIGENICITY
ZEB1
CSC
EMT
PDAC
TGF-β
let-7
metastasis
miR-100
miR-125b
microRNAs
stemness
Publication Status
Published
Date Publish Online
2018-08-13