Exponential equilibration of genetic circuits using entropy methods
File(s)Cañizo2019_Article_ExponentialEquilibrationOfGene.pdf (1.39 MB)
Published version
Author(s)
Cañizo, Jose Alfredo
Carrillo de la Plata, J
Pájaro, Manuel
Type
Journal Article
Abstract
We analyse a continuum model for genetic circuits based on a partial integro-differential equation initially proposed in Friedman et al. (Phys Rev Lett 97(16):168302, 2006) as an approximation of a chemical master equation. We use entropy methods to show exponentially fast convergence to equilibrium for this model with explicit bounds. The asymptotic equilibration for the multidimensional case of more than one gene is also obtained under suitable assumptions on the equilibrium stationary states. The asymptotic equilibration property for networks involving one and more than one gene is investigated via numerical simulations.
Date Issued
2019-01
Date Acceptance
2018-07-30
Citation
Journal of Mathematical Biology, 2019, 78 (1-2), pp.373-411
ISSN
0303-6812
Publisher
Springer Verlag
Start Page
373
End Page
411
Journal / Book Title
Journal of Mathematical Biology
Volume
78
Issue
1-2
Copyright Statement
© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Identifier
https://link.springer.com/article/10.1007%2Fs00285-018-1277-z
Grant Number
EP/P031587/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Biology
Mathematical & Computational Biology
Life Sciences & Biomedicine - Other Topics
REGULATORY NETWORKS
BURST FREQUENCY
MODELS
FRAGMENTATION
EXPRESSION
NOISE
STOCHASTICITY
SIMULATION
EQUATIONS
DECAY
35B40
39B99
65M99
92Dxx
Bioinformatics
01 Mathematical Sciences
06 Biological Sciences
Publication Status
Published
Date Publish Online
2018-08-17