Transcranial ultrasound stimulation effect in the redundant and synergistic networks consistent across macaques
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Low-intensity transcranial ultrasound stimulation (TUS) is a noninvasive technique that safely alters neural activity, reaching deep brain areas with good spatial accuracy. We investigated the effects of TUS in macaques using a recent metric, the synergy minus redundancy rank gradient, which quantifies different kinds of neural information processing. We analyzed this high-order quantity on the fMRI data after TUS in two targets: the supplementary motor area (SMA-TUS) and the frontal polar cortex (FPC-TUS). The TUS produced specific changes at the limbic network at FPC-TUS and the motor network at SMA-TUS and altered the sensorimotor, temporal, and frontal networks in both targets, mostly consistent across macaques. Moreover, there was a reduction in the structural and functional coupling after both stimulations. Finally, the TUS changed the intrinsic high-order network topology, decreasing the modular organization of the redundancy at SMA-TUS and increasing the synergistic integration at FPC-TUS.
Date Issued
2024-12-10
Date Acceptance
2024-05-17
Citation
Network Neuroscience, 2024, 8 (4), pp.1032-1050
ISSN
2472-1751
Publisher
The MIT Press
Start Page
1032
End Page
1050
Journal / Book Title
Network Neuroscience
Volume
8
Issue
4
Copyright Statement
© 2024 Massachusetts Institute of Technology Published under a Creative Commons Attribution 4.0 International (CC BY 4.0) license
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/39735508
PII: netn_a_00388
Subjects
CONSCIOUSNESS
fMRI
FUNCTIONAL CONNECTIVITY CHANGES
High-order
INTEGRATION
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
PREFRONTAL CORTEX
Redundancy
Science & Technology
SEGREGATION
SOFTWARE
Synergy
TUS
VISUALIZATION
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2024-12-10