Fabrication and characterization of ZrO2 incorporated SiO2–CaO–P2O5 bioactive glass scaffolds
File(s)
Accepted version
Author(s)
Kumar, Pawan
Kumar, Vinod
Kumar, Rajnish
Kumar, Ravinder
Pruncu, Catalin I
Type
Journal Article
Abstract
Sol-gel chemistry offers a flexible, widely accepted methodology that enables the creation of a new generation of bioactive glass (BG). In the current study, a sol-gel method was used to synthesize ZrO2 incorporated 56SiO2–34CaO–10P2O5 mol% bioactive glass. The highly crystalline structure was composed of small zirconium oxide nanoparticles (ZrO2) of less than 200 nm in size. It was successfully fabricated using a hydrothermal method. Polyurethane foam (PU) was selected to fabricate a highly porous BG-ZrO2 scaffold using a foam replica technique. The physicochemical, morphological properties of the BG-ZrO2 compositions were evaluated using X-ray diffraction (XRD), Fourier transforms infrared (FTIR), thermo-gravimetric analysis (TGA), transmission electron microscope (TEM) and scanning electron microscope (SEM) with energy dispersive spectroscopy (EDS). In-vitro degradation analysis of the BG-ZrO2 scaffolds was performed after immersion of the samples in simulated body fluid (SBF). The incorporation of ZrO2 nanoparticles into the bioactive glass matrix enhances both the mechanical strength and thermal stability. Since the novel formed BG-ZrO2 scaffolds possesses respectable antibacterial properties against some bacterial strains, this renders it an ideal tissue engineering substitute, capable of reducing failure rates in implants.
Date Issued
2020-09
Date Acceptance
2020-05-10
Citation
Journal of the Mechanical Behavior of Biomedical Materials, 2020, 109, pp.103854-103854
ISSN
1751-6161
Publisher
Elsevier BV
Start Page
103854
End Page
103854
Journal / Book Title
Journal of the Mechanical Behavior of Biomedical Materials
Volume
109
Copyright Statement
© 2020 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Subjects
Antibacterial properties
Bioactive glass
Foam replica
Sol-gel
ZrO2 nanoparticles
Biomedical Engineering
0903 Biomedical Engineering
0912 Materials Engineering
0913 Mechanical Engineering
Publication Status
Published
Article Number
103854
Date Publish Online
2020-05-12