Associations between Mycobacterium tuberculosis strains and phenotypes
File(s)
Author(s)
Brown, T
Nikolayevskyy, VN
Velji, P
Drobniewski, FA
Type
Journal Article
Abstract
To inform development of tuberculosis (TB) control strategies, we characterized a total of 2,261 Mycobacterium tuberculosis complex isolates by using multiple phenotypic and molecular markers, including polymorphisms in repetitive sequences (spoligotyping and variable-number tandem repeats [VNTRs]) and large sequence and single-nucleotide polymorphisms. The Beijing family was strongly associated with multidrug resistance (p = 0.0001), and VNTR allelic variants showed strong associations with spoligotyping families: ≥5 copies at exact tandem repeat (ETR) A, ≥2 at mycobacterial interspersed repetitive unit 24, and ≥3 at ETR-B associated with the East African-Indian and M. bovis strains. All M. tuberculosis isolates were differentiated into 4 major lineages, and a maximum parsimony tree was constructed suggesting a more complex phylogeny for M. africanum. These findings can be used as a model of pathogen global diversity.
Date Issued
2010-02-01
Date Acceptance
2010-02-01
Citation
Emerging Infectious Diseases, 2010, 16 (2), pp.272-280
ISSN
1080-6059
Publisher
Centers for Disease Control and Prevention
Start Page
272
End Page
280
Journal / Book Title
Emerging Infectious Diseases
Volume
16
Issue
2
Copyright Statement
Emerging Infectious Diseases is published by the Centers for Disease Control and Prevention, a U.S. Government agency. Therefore, all materials published in Emerging Infectious Diseases are in the public domain and can be used without permission. Proper citation, however, is required.