Natural polymorphisms in mycobacterium tuberculosis conferring resistance to delamanid in drug-naïve patients.
File(s)
Author(s)
Type
Journal Article
Abstract
Mutations in the genes of the F420 signaling pathway, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, of Mycobacterium tuberculosis (Mtb) complex can lead to delamanid resistance. We searched for such mutations among 129 Mtb strains from Asia, South-America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes. For ten strains with mutations, we determined the minimum inhibitory concentration (MIC) of delamanid. We found one strain from a delamanid-naïve patient carrying the natural polymorphism Tyr29del (ddn) that was associated with a critical MIC to delamanid.
Date Issued
2020-08-31
Date Acceptance
2020-08-19
Citation
Antimicrobial Agents and Chemotherapy, 2020, 64 (11), pp.1-5
ISSN
0066-4804
Publisher
American Society for Microbiology
Start Page
1
End Page
5
Journal / Book Title
Antimicrobial Agents and Chemotherapy
Volume
64
Issue
11
Copyright Statement
© 2020 Reichmuth et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/.
License URL
Sponsor
Wellcome Trust
Wellcome Trust
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32868333
PII: AAC.00513-20
Grant Number
104803/Z/14/Z
WDAI_P83556
Subjects
International epidemiology Databases to Evaluate AIDS (IeDEA)
0605 Microbiology
1108 Medical Microbiology
1115 Pharmacology and Pharmaceutical Sciences
Microbiology
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2020-10-20