Islet autoimmunity in human type 1 diabetes: initiation and progression from the perspective of the beta cell
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Published version
Author(s)
Thompson, Peter J
Pipella, Jasmine
Rutter, Guy
Gaisano, Herbert Y
Santamaria, Pere
Type
Journal Article
Abstract
Type 1 diabetes results from the poorly understood process of islet autoimmunity, which ultimately leads to the loss of functional pancreatic beta cells. Mounting evidence supports the notion that the activation and evolution of islet autoimmunity in genetically susceptible people is contingent upon early life exposures affecting the islets, especially beta cells. Here, we review some of the recent advances and studies that highlight the roles of these changes as well as
antigen presentation and stress response pathways in beta cells in the onset and propagation of the autoimmune process in type 1 diabetes. Future progress in this area holds promise for advancing islet- and beta cell-directed therapies that could be implemented in the early stages of
the disease and could be combined with immunotherapies.
antigen presentation and stress response pathways in beta cells in the onset and propagation of the autoimmune process in type 1 diabetes. Future progress in this area holds promise for advancing islet- and beta cell-directed therapies that could be implemented in the early stages of
the disease and could be combined with immunotherapies.
Date Issued
2023-11
Date Acceptance
2023-05-31
Citation
Diabetologia, 2023, 66 (11), pp.1971-1982
ISSN
0012-186X
Publisher
Springer
Start Page
1971
End Page
1982
Journal / Book Title
Diabetologia
Volume
66
Issue
11
Copyright Statement
© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Identifier
https://link.springer.com/article/10.1007/s00125-023-05970-z
Publication Status
Published
Date Publish Online
2023-07-25