KlebPhaCol: a community-driven resource for Klebsiella research identified a novel phage family
File(s)
Published version
Author(s)
Rothschild-Rodriguez, Daniela
Lambon, Kai S
Kushwaha, Simran Krishnakant
Garushyants, Sofya K
Ertelt, Moritz
Type
Journal Article
Abstract
The growing threat of multidrug-resistant Klebsiella pneumoniae, coupled with its role in gut colonisation, has intensified the search for new treatments, including bacteriophage therapy. Despite increasing documentation of Klebsiella-targeting phages, clinical applications remain limited, with key phage–bacteria interactions still poorly understood. A major obstacle is fragmented access to well-characterised phage–bacteria pairings, restricting the collective advancement of therapeutic and mechanistic insights. To address this gap, we created the Klebsiella Phage Collection (KlebPhaCol), an open resource comprising 52 phages and 74 Klebsiella isolates, characterised at phenotypic and genomic levels. These phages span six families—including a novel family, Felixviridae, associated with the human gut—and target 20 sequence types (including ST258, ST11, and ST14) and 19 capsular-locus types (including KL1 and KL2), across 6 Klebsiella species. Freely accessible at www.klebphacol.org, KlebPhaCol invites the scientific community to both use and contribute to this resource, fostering collaborative research and a deeper understanding of Klebsiella-phage interactions beyond therapeutic use.
Date Issued
2025-11-26
Date Acceptance
2025-09-23
Citation
Nucleic Acids Research, 2025, 53 (21)
ISSN
0305-1048
Publisher
Oxford University Press (OUP)
Journal / Book Title
Nucleic Acids Research
Volume
53
Issue
21
Copyright Statement
© The Author(s) 2025. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/41261852
PII: 8328384
Subjects
Bacteriophages
Klebsiella pneumoniae
Klebsiella
Humans
Genome, Viral
Phylogeny
Klebsiella Infections
Publication Status
Published
Coverage Spatial
England
Article Number
gkaf1122
Date Publish Online
2025-11-20