Ammonium [11C]thiocyanate: revised preparation and reactivity studies of a versatile nucleophile for carbon-11 radiolabelling
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Published version
Author(s)
Haywood, tom
Cesarec, Sara
Kealey, Steven
Plisson, christophe
Miller, P
Type
Journal Article
Abstract
Herein we report the preparation of ammonium [11C]thiocyanate via the reaction of [11C]CS2 with ammonia. The [11C]SCN− ion is demonstrated as a potent nucleophile that can be used to readily generate a range of 11C-labelled thiocyanate molecules in high conversions. Furthermore, novel 11C-labelled thiazolone molecules can be easily prepared from the intermediate α-thiocyanatophenones via an acid mediated cyclisation reaction.
Date Issued
2018-08-01
Date Acceptance
2018-05-10
Citation
MedChemComm, 2018, 9, pp.1311-1314
ISSN
2040-2503
Publisher
Royal Society of Chemistry
Start Page
1311
End Page
1314
Journal / Book Title
MedChemComm
Volume
9
Copyright Statement
© The Royal Society of Chemistry 2018. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/)
Sponsor
Engineering & Physical Science Research Council (E
The Royal Society
Grant Number
EP/L025140/1
RG110449
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Chemistry, Medicinal
Pharmacology & Pharmacy
POSITRON-EMISSION-TOMOGRAPHY
PET
RADIOPHARMACEUTICALS
RADIOCHEMISTRY
THIOCYANATE
TANAPROGET
CHEMISTRY
DISEASE
REAGENT
F-18
0304 Medicinal and Biomolecular Chemistry
0305 Organic Chemistry
1115 Pharmacology and Pharmaceutical Sciences
Publication Status
Published
Date Publish Online
2018-07-02