The stability of blood Eosinophils in chronic obstructive pulmonary disease
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Blood eosinophils are a predictive biomarker of inhaled corticosteroid response in chronic obstructive pulmonary disease (COPD). We investigated blood eosinophil stability over 1 year using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2019 thresholds of < 100, 100- < 300 and ≥ 300 eosinophils/μL in 225 patients from the COPDMAP cohort. Blood eosinophils showed good stability (rho: 0.71, p < 0.001, ICC 0.84), and 69.3% of patients remained in the same eosinophil category at 1 year. 85.3% of patients with eosinophils < 100 cells/μL had stable counts. The majority of blood eosinophil counts remain stable over 1 year using the GOLD 2019 thresholds.
Date Issued
2020-01-10
Date Acceptance
2020-01-05
Citation
Respiratory Research, 2020, 21 (1)
ISSN
1465-9921
Publisher
BioMed Central
Journal / Book Title
Respiratory Research
Volume
21
Issue
1
Copyright Statement
© The Author(s). 2020. This article is distributed under the terms of the Creative Commons Attribution 4.0International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, andreproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link tothe Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Sponsor
Medical Research Council (MRC)
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31924207
PII: 10.1186/s12931-020-1279-4
Grant Number
RM63G0377
Subjects
Airway inflammation
COPD
Eosinophil
Publication Status
Published
Coverage Spatial
England
Article Number
ARTN 15