Epigenome Modifying Tools In Asthma
File(s)
Accepted version
Published version
Author(s)
Brook, PO
Perry, M
Adcock
Durham, AL
Type
Journal Article
Abstract
Asthma is chronic disease which causes recurrent breathlessness affecting 300 million people worldwide of whom 250,000 die annually. The epigenome is a set of heritable modifications and tags that affect the genome without changing the intrinsic DNA sequence. These marks include DNA methylation, modifications to histone proteins around which DNA is wrapped and expression of non-coding RNA. Alterations in all of these processes have been reported in patients with asthma. In some cases these differences are linked to disease severity and susceptibility and may account for the limited value of genetic studies in asthma. Animal models of asthma suggest that epigenetic modifications and processes are linked to asthma and may be tractable targets for therapeutic intervention.
Date Issued
2015-10-07
Date Acceptance
2015-05-11
Citation
Epigenomics, 2015, 7 (6), pp.1017-1032
ISSN
1750-192X
Publisher
Future Medicine
Start Page
1017
End Page
1032
Journal / Book Title
Epigenomics
Volume
7
Issue
6
Copyright Statement
© 2015 P Brook et al. This article is distributed under the terms of the Creative
Commons Attribution License 4.0 which permits any
use,distribution, and reproduction in any medium, provided
the original author(s)and the source are credited. To view a
copy of the license, visit http://creativecommons.org/licenses/
by/4.0/
Commons Attribution License 4.0 which permits any
use,distribution, and reproduction in any medium, provided
the original author(s)and the source are credited. To view a
copy of the license, visit http://creativecommons.org/licenses/
by/4.0/
License URL
Subjects
asthma
DNA methylation
epigenetics
histone modification
miRNA
T cell
therapeutics
Publication Status
Published