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Protocol for repeated Plasmodium chabaudi infection in a murine malaria model
File(s)
Author(s)
Bruno, Federica
Langhorne, Jean
Lo Celso, Cristina
Type
Journal Article
Abstract
In malaria-endemic regions, individuals experience repeated malaria infection throughout life. Here, we present a protocol to investigate the immunological mechanisms triggered by repeated exposure using a murine model of sequential infections with the rodent parasite Plasmodium chabaudi chabaudi. We provide a detailed and standardized series of steps covering primary infection, natural recovery without treatment, and subsequent secondary infection. This approach offers a robust framework to investigate the effects and long-term consequences of repeated malaria infections on the host.
Date Acceptance
2026-09-04
Citation
STAR Protocols
URI
ISSN
2666-1667
Publisher
Elsevier
Journal / Book Title
STAR Protocols
Copyright Statement
Copyright This paper is embargoed until publication. Once published the Version of Record (VoR) will be available on immediate open access.
License URL
Publication Status
Accepted