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Restriction point regulation at the crossroads between quiescence and cell proliferation
File(s)
1873-3468.13867.pdf (1.14 MB)
Published version
OA Location
Author(s)
Pennycook, Betheney R
Barr, Alexis R
Type
Journal Article
Abstract
The coordination of cell proliferation with reversible cell cycle exit into quiescence is crucial for the development of multicellular organisms and for tissue homeostasis in the adult. The decision between quiescence and proliferation occurs at the restriction point, which is widely thought to be located in the G1 phase of the cell cycle, when cells integrate accumulated extracellular and intracellular signals to drive this binary cellular decision. On the molecular level, decision-making is exerted through the activation of cyclin-dependent kinases (CDKs). CDKs phosphorylate the retinoblastoma (Rb) transcriptional repressor to regulate the expression of cell cycle genes. Recently, the classical view of restriction point regulation has been challenged. Here, we review the latest findings on the activation of CDKs, Rb phosphorylation and the nature and position of the restriction point within the cell cycle.
Date Issued
2020-07-01
Date Acceptance
2020-06-10
Citation
FEBS Letters, 2020, 594, pp.2046-2060
URI
DOI
ISSN
0014-5793
Publisher
Elsevier
Start Page
2046
End Page
2060
Journal / Book Title
FEBS Letters
Volume
594
Copyright Statement
© 2020 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Sponsor
Cancer Research UK
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32564372
Grant Number
C63833/A25729
Subjects
cell cycle
cyclin
cyclin-dependent kinase
proliferation
quiescence
restriction point
single-cell imaging
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2020-06-21