On the characterisation of the heterogeneous mechanical response of human brain tissue
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Published version
Author(s)
Forte, AE
Gentleman, SM
Dini, D
Type
Journal Article
Abstract
The mechanical
characterization of brain tissue is a complex task scientists have tried to
accomplish for over fifty years.
The results
in literature
often differ by orders of magnitude
because of the lack of a standard testing protocol. Different testing conditions (inc
luding
humidity, temperature, strain rate),
the
methodology
adopted
,
the variety of
the
species
analysed, are all potential sources of
discrepancies
in the measurements.
In this work we
present a rigorous experimental investigation on the mechanical proper
ties of human brain
,
covering both
gr
e
y and white matter.
The influence of testing conditions
is
also shown and
thoroughly
discussed.
The material characterisation performed is finally adopted to provide
inputs to
a
mathematical formulation suitable for
nu
merical s
i
mulations of brain deformation
during surgical procedures
.
characterization of brain tissue is a complex task scientists have tried to
accomplish for over fifty years.
The results
in literature
often differ by orders of magnitude
because of the lack of a standard testing protocol. Different testing conditions (inc
luding
humidity, temperature, strain rate),
the
methodology
adopted
,
the variety of
the
species
analysed, are all potential sources of
discrepancies
in the measurements.
In this work we
present a rigorous experimental investigation on the mechanical proper
ties of human brain
,
covering both
gr
e
y and white matter.
The influence of testing conditions
is
also shown and
thoroughly
discussed.
The material characterisation performed is finally adopted to provide
inputs to
a
mathematical formulation suitable for
nu
merical s
i
mulations of brain deformation
during surgical procedures
.
Date Issued
2016-12-08
Date Acceptance
2016-11-20
Citation
Biomechanics and Modeling in Mechanobiology, 2016, 16 (3), pp.907-920
ISSN
1617-7959
Publisher
Springer Verlag (Germany)
Start Page
907
End Page
920
Journal / Book Title
Biomechanics and Modeling in Mechanobiology
Volume
16
Issue
3
Copyright Statement
© The Author(s) 2016. Open Access
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Sponsor
Commission of the European Communities
Engineering & Physical Science Research Council (E
Parkinson's UK
Engineering & Physical Science Research Council (EPSRC)
Grant Number
270460
EP/K503733/1
J-1402
EP/N025954/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Technology
Biophysics
Engineering, Biomedical
Engineering
Human brain tissue
Mechanical properties
Abaqus
FE modelling
Humidity and temperature
Heterogeneous
MAGNETIC-RESONANCE ELASTOGRAPHY
WHITE-MATTER
IN-VIVO
CONSTITUTIVE MODEL
LARGE-STRAIN
HEAD-INJURY
SHEAR
BEHAVIOR
HYDROCEPHALUS
BIOMECHANICS
Biomedical Engineering
0913 Mechanical Engineering
0903 Biomedical Engineering
Publication Status
Published