Effect of time of day and seasonal variation on bronchodilator responsiveness: the SPIRO-TIMETRY study
File(s)
Published version
Author(s)
Knox-Brown, Ben
Kon, Fu Chuen
Sylvester, Karl Peter
Jha, Akhilesh
Type
Journal Article
Abstract
We investigated the association between time of day and season of testing on the level of bronchodilator responsiveness in a hospital-based population. We found that per 1-hour increment in the working day, the odds of a positive bronchodilator response decreased by 8%. A similar effect was seen when time of day was dichotomised into morning and afternoon time periods. When stratifying by referral reason, the impact of time of day was only seen in those referred for asthma/query asthma. We also found that bronchodilator responsiveness was more common in winter months compared with the rest of the year.
Date Issued
2025-06-01
Date Acceptance
2025-03-01
Citation
Thorax, 2025, 80 (6), pp.395-397
ISSN
0040-6376
Publisher
BMJ
Start Page
395
End Page
397
Journal / Book Title
Thorax
Volume
80
Issue
6
Copyright Statement
© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/40068921
PII: thorax-2024-222773
Subjects
Asthma
Lung Physiology
Respiratory Measurement
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2025-03-11