Shock-induced intermetallic reactions have previously been shown to occur on a nanosecond timescale, with the role of mass mixing processes driven by inter-facial shear at material interfaces suggested as a possible explanation. Experimental setups allowing the role of friction on these mechanisms to be considered are presented. Simulations show that the use of an impedance mismatch, shock driven experimental setup should allow sliding velocities of 50 - 100 m s⁻¹ to be attained with mechanical mixing the main reaction mechanism. A second setup utilising the oblique impact of small spherical projectiles upon a target plate is predicted to enable much higher sliding velocities of up to 2 Km s⁻¹ to be attained with thermally driven diffusion reaction mechanisms becoming dominant.