Quantifying hypoxia with diffuse reflectance spectroscopy for advanced prognostication and real-time response monitoring in rectal cancer: an in vivo feasibility study
File(s)
Accepted version
Author(s)
Type
Conference Paper
Abstract
Tumour hypoxia is a critical factor in treatment failure and resistance, and its accurate measurement with diffuse reflectance spectroscopy (DRS) could be used for prognostic and response monitoring purposes. In this in vivo characterisation study, we sequentially measured oxygenation trends over the entire course of tumour growth in mice using a multi-depth, fibre-optic DRS probe. Results demonstrated a clear downtrend in oxygenation over time. This progression was not always linear, with significant heterogeneity over time and between mice. Our findings will be further validated against gold standards prior to investigating whether hypoxia can be used to predict radiotherapy responses.
Editor(s)
Gannot, Israel
Roodenko, Katy
Date Issued
2023-04-27
Date Acceptance
2023-04-01
Citation
Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXIII, 2023, 12372, pp.1-6
ISBN
9781510658493
ISSN
1605-7422
Publisher
SPIE
Start Page
1
End Page
6
Journal / Book Title
Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXIII
Volume
12372
Copyright Statement
Copyright 2023 Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. Teddy Fletcher, Elena Monfort-Sanchez, Meysam Keshavarz, James Avery, Hutan Ashrafian, Ara W. Darzi, and Alex J. Thompson "Quantifying hypoxia with diffuse reflectance spectroscopy for advanced prognostication and real-time response monitoring in rectal cancer: an in vivo feasibility study", Proc. SPIE 12372, Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXIII, 1237206 (27 April 2023); https://doi.org/10.1117/12.2648827
Identifier
https://www.spiedigitallibrary.org/conference-proceedings-of-spie/12372/2648827/Quantifying-hypoxia-with-diffuse-reflectance-spectroscopy-for-advanced-prognostication-and/10.1117/12.2648827.full
Source
Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXIII
Publication Status
Published
Start Date
2023-01-28
Finish Date
2023-02-03
Coverage Spatial
San Francisco, California, United States
Date Publish Online
2023-04-27