Background: Prematurity is generally marred by respiratory challenges including respiratory distress syndrome (RDS). The more premature a baby is, the greater the risk for RDS and the poorer the survival rate, if no effective intervention geared towards the improvement of neonatal respiratory support is offered.

Methods: A simple consecutive recruitment of preterm babies who met the inclusion criteria was done, and each one received one form of neonatal respiratory support application or another available in the Neoroom.

Results: Twelve preterm babies have so far been recruited, with ten of them supported on the combination of the politeheart continuous positive airway pressure (CPAP) and the politeoxygen splitter system (PSS). There was 100% overall neonatal respiratory support success rate in the Neoroom.

Conclusion: There is an urgent need for scaling up of availability of neonatal respiratory support devices, particularly the combinations of politeheartCPAP systems across Nigeria facilities and the LMICs. This will ultimately improve neonatal survival.