The potential of electrocardiography for cardiac risk prediction in chronic and end-stage kidney disease
Author(s)
Skampardoni, Sofia
Poulikakos, Dimitrios
Malik, Marek
Green, Darren
Kalra, Philip A
Type
Journal Article
Abstract
Cardiovascular mortality is very high in chronic and end-stage kidney disease (ESKD). However, risk stratification data are lacking. Sudden cardiac deaths are among the most common cardiovascular causes of death in these populations. As a result, many studies have assessed the prognostic potential of various electrocardiographic parameters in the renal population. Recent data from studies of implantable loop recordings in haemodialysis patients from five different countries have shed light on a pre-eminent bradyarrhythmic risk of mortality. Importantly, heart block addressed by permanent pacing system was detected in a proportion of patients during the prolonged recording periods. Standard electrocardiogram is inexpensive, non-invasive and easily accessible. Hence, risk prediction models using this simple investigation tool could easily translate into clinical practice. We believe that electrocardiographic assessment is currently under-valued in renal populations. For this review, we identified studies from the preceding 10 years that assessed the use of conventional and novel electrocardiographic biomarkers as risk predictors in chronic and ESKD. The review indicates that conventional electrocardiographic markers are not reliable for risk stratification in the renal populations. Novel parameters have shown promising results in smaller studies, but further validation in larger populations is required.
Date Issued
2019-07-01
Date Acceptance
2018-07-04
Citation
Nephrology Dialysis Transplantation, 2019, 34 (7), pp.1089-1098
ISSN
0931-0509
Publisher
Oxford University Press (OUP)
Start Page
1089
End Page
1098
Journal / Book Title
Nephrology Dialysis Transplantation
Volume
34
Issue
7
Copyright Statement
© The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices). This is a pre-copy-editing, author-produced version of an article accepted for publication in Nephrology Dialysis Transplantation following peer review. The definitive publisher-authenticated version is available online at: https://dx.doi.org/10.1093/ndt/gfy255
Sponsor
British Heart Foundation
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/30085289
PII: 5067138
Grant Number
NH/16/2/32499
Subjects
CKD
ECG
ESRD
cardiovascular
Urology & Nephrology
1103 Clinical Sciences
Publication Status
Published
Coverage Spatial
England
Article Number
ARTN gfy255
Date Publish Online
2018-08-06