Relationship between lta4h promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syndrome and its prevention with prednisone
File(s)ofad379.pdf (404.53 KB)
Published version
Author(s)
Type
Journal Article
Abstract
The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not find an association between LTA4H genotype and TB-IRIS incidence or prednisone efficacy.
Date Issued
2023-07-01
Date Acceptance
2023-07-14
Citation
Open Forum Infectious Diseases, 2023, 10 (7), pp.1-4
ISSN
2328-8957
Publisher
Oxford University Press
Start Page
1
End Page
4
Journal / Book Title
Open Forum Infectious Diseases
Volume
10
Issue
7
Copyright Statement
© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases
Society of America. This is an Open Access article distributed under the terms of the
Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which
permits unrestricted reuse, distribution, and reproduction in any medium, provided the original
work is properly cited.
Society of America. This is an Open Access article distributed under the terms of the
Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which
permits unrestricted reuse, distribution, and reproduction in any medium, provided the original
work is properly cited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/37520416
PII: ofad379
Subjects
corticosteroids
immune reconstitution inflammatory syndrome
IRIS
LTA4H genotype
tuberculosis
Publication Status
Published
Coverage Spatial
United States
Article Number
ARTN ofad37
Date Publish Online
2023-07-17