Neurological and neurodevelopmental effects of Covid and MIS-C on children
File(s)
Accepted version
Supporting information
Author(s)
Type
Journal Article
Abstract
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been shown to cause a unique disease phenotype in the paediatric population compared to adults, following the emergence of Multisystem Inflammatory Syndrome of Children (MIS-C) and Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS). Over the course of the pandemic, neurological symptoms associated with SARS-CoV-2 have been reported in the paediatric population. The neurological and neurodevelopmental sequelae of both acute SARS-CoV-2 infection and MIS-C/PIMS-TS in the paediatric population are not well understood. Little is known about the underlying pathophysiology and the potential neurovirulence of SARS-CoV-2. Further awareness and research are needed on the neurological sequelae and long-term consequences of SARS-CoV-2 on the developing brain.
Date Issued
2025-11-11
Date Acceptance
2025-10-15
Citation
Pediatric Research
ISSN
0031-3998
Publisher
Springer Nature [academic journals on nature.com]
Journal / Book Title
Pediatric Research
Copyright Statement
Copyright © 2025 Springer Nature. This is the author’s accepted manuscript made available under a CC-BY licence in accordance with Imperial’s Research Publications Open Access policy (www.imperial.ac.uk/oa-policy)
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/41219464
PII: 10.1038/s41390-025-04564-2
Subjects
COHORT
Life Sciences & Biomedicine
MULTICENTER
MULTISYSTEM INFLAMMATORY SYNDROME
OUTCOMES
Pediatrics
RISK-FACTORS
SARS-COV-2 INFECTION
Science & Technology
TIME
Publication Status
Published online
Coverage Spatial
United States
Date Publish Online
2025-11-11