Knowns and unknowns of tissue-resident memory T cells
File(s)
Author(s)
Altmann, Daniel M
Type
Journal Article
Abstract
Advances in transcriptomics and other approaches are shedding considerable light on tissue‐resident immune cells as distinct from recirculating cells. The advances encompass antigen‐presenting cell subsets, Tregs and importantly, tissue‐resident memory cells (TRM). What are the transcriptional programmes and functional properties that distinguish the requirements for an effective tissue resident cell in brain relative to lung, skin, adipose tissue or the genital tract? Another important conundrum has been the extent to which TRM cells are specialized either as a ‘sense and alarm’ population or as a local, primed, effector cell population in themselves. These are questions that challenge immunologists to stop thinking in terms of a generic, model, immune response and focus instead on events in the tissue in question.
Date Issued
2019-05-01
Date Acceptance
2019-04-01
Citation
Immunology, 2019, 157 (1), pp.1-2
ISSN
0019-2805
Publisher
Wiley
Start Page
1
End Page
2
Journal / Book Title
Immunology
Volume
157
Issue
1
Copyright Statement
© 2019 John Wiley & Sons Ltd. This is the accepted version of the following article: Altmann, D. M. (2019), Knowns and unknowns of tissue‐resident memory T cells. Immunology, 157: 1-2., which has been published in final form at https://dx.doi.org/10.1111/imm.13062
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000465088700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Publication Status
Published
Date Publish Online
2019-04-11