Six month mortality in patients with COVID-19 and non-COVID-19 viral pneumonitis managed with veno-venous extracorporeal membrane oxygenation
File(s)ASAIO submission COVID-19 ECMO (clean).docx (121.33 KB)
Accepted version
Author(s)
Type
Journal Article
Abstract
A significant proportion of patients with COVID-19 develop acute respiratory distress syndrome (ARDS) with high risk of death. The efficacy of veno-venous extracorporeal membrane oxygenation (VV-ECMO) for COVID-19 on longer-term outcomes, unlike in other viral pneumonias, is unknown. In this study, we aimed to compare the 6 month mortality of patients receiving VV-ECMO support for COVID-19 with a historical viral ARDS cohort. Fifty-three consecutive patients with COVID-19 ARDS admitted for VV-ECMO to the Royal Brompton Hospital between March 17, 2020 and May 30, 2020 were identified. Mortality, patient characteristics, complications, and ECMO parameters were then compared to a historical cohort of patients with non-COVID-19 viral pneumonia. At 6 months survival was significantly higher in the COVID-19 than in the non-COVID-19 viral pneumonia cohort (84.9% vs. 66.0%, p = 0.040). Patients with COVID-19 had an increased Murray score (3.50 vs. 3.25, p = 0.005), a decreased burden of organ dysfunction (sequential organ failure score score [8.76 vs. 10.42, p = 0.004]), an increased incidence of pulmonary embolism (69.8% vs. 24.5%, p < 0.001) and in those who survived to decannulation longer ECMO runs (19 vs. 11 days, p = 0.001). Our results suggest that survival in patients supported with EMCO for COVID-19 are at least as good as those treated for non-COVID-19 viral ARDS.
Date Issued
2021-09-01
Date Acceptance
2021-06-16
Citation
ASAIO Journal, 2021, 67 (9), pp.982-988
ISSN
1058-2916
Publisher
Lippincott, Williams & Wilkins
Start Page
982
End Page
988
Journal / Book Title
ASAIO Journal
Volume
67
Issue
9
Copyright Statement
© ASAIO 2021. This is a non-final version of an article published in final form in ASAIO Journal https://journals.lww.com/asaiojournal/Fulltext/2021/10000/Six_Month_Mortality_in_Patients_with_COVID_19_and.4.aspx
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/34144551
PII: 00002480-900000000-98219
Subjects
Science & Technology
Technology
Life Sciences & Biomedicine
Engineering, Biomedical
Transplantation
Engineering
COVID-19
acute respiratory distress syndrome
viral pneumonia
extracorporeal membrane oxygenation
ACUTE RESPIRATORY-FAILURE
SURVIVAL
ECMO
ARDS
0903 Biomedical Engineering
Biomedical Engineering
Publication Status
Published
Coverage Spatial
United States