Silent nucleotide polymorphisms and a phylogeny for Mycobacterium tuberculosis
File(s)
Author(s)
Baker, LV
Brown, T
Maiden, MCJM
Drobniewski, FA
Type
Journal Article
Abstract
Much remains unknown of the phylogeny and evolution of Mycobacterium tuberculosis, an organism that kills 2 million people annually. Using a population-based approach that analyzes multiple loci around the chromosome, we demonstrate that neutral genetic variation in genes associated with antimicrobial drug resistance has sufficient variation to construct a robust phylogenetic tree for M. tuberculosis. The data describe a clonal population with a minimum of four distinct M. tuberculosis lineages, closely related to M. bovis. The lineages are strongly geographically associated. Nucleotide substitutions proven to cause drug resistance are distributed throughout the tree, whereas nonsynonymous base substitutions unrelated to drug resistance have a restricted distribution. The phylogenetic structure is concordant with all the previously described genotypic and phenotypic groupings of M. tuberculosis strains and provides a unifying framework for both epidemiologic and evolutionary analysis of M. tuberculosis populations.
Date Issued
2004-09-01
Date Acceptance
2004-09-01
Citation
Emerging Infectious Diseases, 2004, 10 (9), pp.1568-1577
ISSN
1080-6059
Publisher
Centers for Disease Control and Prevention
Start Page
1568
End Page
1577
Journal / Book Title
Emerging Infectious Diseases
Volume
10
Issue
9
Copyright Statement
© 2004 Baker L, Brown T, Maiden M, Drobniewski F. Silent nucleotide polymorphisms and a phylogeny for Mycobacterium tuberculosis. Emerg Infect Dis. 2004 Sep. Available from: http://wwwnc.cdc.gov/eid/article/10/9/04-0046
Publication Status
Published