Magnetic resonance imaging and tensor-based morphometry in the MPTP non-human primate model of Parkinson's disease
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Author(s)
Type
Journal Article
Abstract
Parkinson’s disease (PD) is the second most common neurodegenerative disorder producing a variety of motor and cognitive deficits with the causes remaining largely unknown. The gradual loss of the nigrostriatal pathway is currently considered the pivotal pathological event. To better understand the progression of PD and improve treatment management, defining the disease on a structural basis and expanding brain analysis to extra-nigral structures is indispensable. The anatomical complexity and the presence of neuromelanin, make the use of non-human primates an essential element in developing putative imaging biomarkers of PD. To this end, ex vivo T2-weighted magnetic resonance images were acquired from control and 1-methyl-4 phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated marmosets. Volume measurements of the caudate, putamen, and substantia nigra indicated significant atrophy and cortical thinning. Tensor-based morphometry provided a more extensive and hypothesis free assessment of widespread changes caused by the toxin insult to the brain, especially highlighting regional cortical atrophy. The results highlight the importance of developing imaging biomarkers of PD in non-human primate models considering their distinct neuroanatomy. It is essential to further develop these biomarkers in vivo to provide non-invasive tools to detect pre-symptomatic PD and to monitor potential disease altering therapeutics.
Date Issued
2017-07-24
Online Publication Date
2017-07-24
2018-02-07T10:55:38Z
Date Acceptance
2017-06-20
ISSN
1932-6203
Publisher
Public Library of Science (PLoS)
Journal / Book Title
PLoS ONE
Volume
12
Issue
7
Copyright Statement
© 2017 Modo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Source Database
web-of-science
Subjects
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
RAT MODEL
IN-VIVO
SUBSTANTIA-NIGRA
COMMON MARMOSETS
ALPHA-SYNUCLEIN
COGNITIVE IMPAIRMENT
CLINICAL-DIAGNOSIS
CALLITHRIX-JACCHUS
RODENT MODEL
VOLUME LOSS
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Behavior, Animal
Biomarkers
Callithrix
Disease Models, Animal
Female
MPTP Poisoning
Magnetic Resonance Imaging
Male
Parkinson Disease
Substantia Nigra
MD Multidisciplinary
General Science & Technology
Publication Status
Published
Article Number
e0180733