Effects of volume resuscitation on the microcirculation in animal models of lipopolysaccharide sepsis: a systematic review.
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
BACKGROUND: Recent research has identified an increased rate of mortality associated with fluid bolus therapy for severe sepsis and septic shock, but the mechanisms are still not well understood. Fluid resuscitation therapy administered for sepsis and septic shock targets restoration of the macro-circulation, but the pathogenesis of sepsis is complex and includes microcirculatory dysfunction. OBJECTIVE: The objective of the study is to systematically review data comparing the effects of different types of fluid resuscitation on the microcirculation in clinically relevant animal models of lipopolysaccharide-induced sepsis. METHODS: A structured search of PubMed/MEDLINE and EMBASE for relevant publications from 1 January 1990 to 31 December 2015 was performed, in accordance with PRISMA guidelines. RESULTS: The number of published papers on sepsis and the microcirculation has increased steadily over the last 25 years. We identified 11 experimental animal studies comparing the effects of different fluid resuscitation regimens on the microcirculation. Heterogeneity precluded any meta-analysis. CONCLUSIONS: Few animal model studies have been published comparing the microcirculatory effects of different types of fluid resuscitation for sepsis and septic shock. Biologically relevant animal model studies remain necessary to enhance understanding regarding the mechanisms by which fluid resuscitation affects the microcirculation and to facilitate the transfer of basic science discoveries to clinical applications.
Date Issued
2016-11-21
Date Acceptance
2016-11-15
Citation
Intensive Care Medicine Experimental, 2016, 4 (38), pp.1-16
ISSN
2197-425X
Publisher
Springer Open
Start Page
1
End Page
16
Journal / Book Title
Intensive Care Medicine Experimental
Volume
4
Issue
38
Copyright Statement
© The Author(s). 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International
License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium,
provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and
indicate if changes were made. The final publication is available at Springer via https://dx.doi.org/10.1186/s40635-016-0112-3
License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium,
provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and
indicate if changes were made. The final publication is available at Springer via https://dx.doi.org/10.1186/s40635-016-0112-3
License URL
Sponsor
MRC Australia
Subjects
Fluid resuscitation
Intravital fluorescence microscopy
Laser Doppler flowmetry
Laser speckle imaging
Lipopolysaccharide
Microcirculation
Oxygen extraction
Sepsis
Septic shock
Sidestream dark-field videomicroscopy
Publication Status
Published