Systematic review of mathematical models exploring the epidemiological impact of future TB vaccines
Author(s)
Harris, RC
Sumner, T
Knight, GM
White, RG
Type
Journal Article
Abstract
Mathematical models are useful for assessing the potential epidemiological impact of future tuberculosis (TB) vaccines. We conducted a systematic review of mathematical models estimating the epidemiological impact of future human TB vaccines. PubMed, Embase and WHO Global Health Library were searched, 3-stage manual sifted, and citation- and reference-tracked, identifying 23 papers. An adapted quality assessment tool was developed, with a resulting median study quality score of 20/28. The literature remains divided as to whether vaccines effective pre- or post-infection would provide greatest epidemiological impact. However, all-age or adolescent/adult targeted prevention of disease vaccines achieve greater and more rapid impact than neonatal vaccines. Mass campaigns alongside routine neonatal vaccination can have profound additional impact. Economic evaluations found TB vaccines overwhelmingly cost-effective, particularly when targeted to adolescents/adults. The variability of impact by setting, age group and vaccine characteristics must be accounted for in the development and delivery of future TB vaccines.
Date Issued
2016-09-26
Date Acceptance
2016-06-21
Citation
Human Vaccines and Immunotherapeutics, 2016, 12 (11), pp.2813-2832
ISSN
2164-5515
Publisher
Taylor & Francis
Start Page
2813
End Page
2832
Journal / Book Title
Human Vaccines and Immunotherapeutics
Volume
12
Issue
11
Sponsor
National Institute for Health Research
National Institute for Health Research
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000388736900026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
HPRU-2012-10047
HPRU-2012-10047
Subjects
Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Immunology
epidemiology
infectious disease dynamics
mathematical model
systematic review
theoretical models
tuberculosis
vaccines
TUBERCULOSIS VACCINES
COST-EFFECTIVENESS
VACCINATION
STRATEGIES
HEALTH
ELIMINATION
PROTECTION
INFECTION
Publication Status
Published
Date Publish Online
2016-09-26