The time-dependent CP asymmetries in B0→π+π− and B0s→K+K− decays are measured using a data sample of p p collisions corresponding to an integrated luminosity of 3.0  fb−1, collected with the LHCb detector at center-of-mass energies of 7 and 8 TeV. The same data sample is used to measure the time-integrated CP asymmetries in B0→K+π− and B0s→π+K− decays. The results are Cπ+π−=−0.34±0.06±0.01, Sπ+π−=−0.63±0.05±0.01, CK+K−=0.20±0.06±0.02, SK+K−=0.18±0.06±0.02, AΔΓK+K−=−0.79±0.07±0.10, AB0CP=−0.084±0.004±0.003, and AB0sCP=0.213±0.015±0.007, where the first uncertainties are statistical and the second systematic. Evidence for CP violation is found in the B0s→K+K− decay for the first time.