Developing a vaccine for human rhinoviruses.
File(s)
Published version
Author(s)
McLean, GR
Type
Journal Article
Abstract
Rhinoviruses (RV's) are common human pathogens of the respiratory tract being the most frequent cause of mild diseases of the upper respiratory tract (common cold) but more importantly they are a major initiator of acute exacerbations of chronic airway diseases. Infections can be life threatening in the latter context however RV -induced common colds have an associated economic cost from loss of productivity due to absence from work or school. There are no appropriate antiviral therapies available and vaccine strategies have failed because of the large number of viral serotypes and the lack of cross-serotype protection generated. Here, approaches past and present for development of a vaccine to these widespread human pathogens are highlighted.
Date Issued
2014-09-30
Date Acceptance
2014-09-23
Citation
Journal of Vaccines and Immunization, 2014, 2 (3), pp.16-20
ISSN
2053-1273
Publisher
Noble Research
Start Page
16
End Page
20
Journal / Book Title
Journal of Vaccines and Immunization
Volume
2
Issue
3
Copyright Statement
© 2014 McLean GR. Published by NobleResearch Publishers. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
License URL
Subjects
chronic airway diseases
human pathogens
immunity
mouse model
rhinovirus
vaccine
Publication Status
Published