Polymorphisms in natural killer cell receptor protein 2D (NKG2D) as a risk factor for Cholangiocarcinoma
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Background and aims: Understanding of the significant genetic risk factors for Cholangiocarcinoma (CC) remains limited. Polymorphisms in the natural killer cell receptor G2D (NKG2D) gene have been shown to increase risk of CC transformation in patients with Primary Sclerosing Cholangitis (PSC). We present a validation study of NKG2D polymorphisms in CC patients without PSC. Methods: Seven common Single Nucleotide Polymorphisms (SNPs) of the NKG2D gene were genotyped in 164 non-PSC related CC subjects and 257 controls with HaploView. The two SNPs that were positively identified in the previous Scandinavian study, rs11053781 and rs2617167, were included. Results: The seven genotyped SNPs were not associated with risk of CC. Furthermore, haplotype analysis revealed that there was no evidence to suggest that any haplotype differs in frequency between cases and controls (P > 0.1). Conclusion: The common genetic variation in NKG2D does not correlate significantly with sporadic CC risk. This is in contrast to the previous positive findings in the Scandinavian study with PSC-patients. The failure to reproduce the association may reflect an important difference between the pathogenesis of sporadic CC and that of PSC-related CC. Given that genetic susceptibility is likely to be multifaceted and complex, further validation studies that include both sporadic and PSC-related CC are required.
Date Issued
2019-03-01
Date Acceptance
2018-06-24
Citation
Journal of Clinical and Experimental Hepatology, 2019, 9 (2), pp.171-175
ISSN
0973-6883
Start Page
171
End Page
175
Journal / Book Title
Journal of Clinical and Experimental Hepatology
Volume
9
Issue
2
Copyright Statement
Crown Copyright © 2018. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Wellcome Trust
Grant Number
105603/Z/14/Z
Subjects
CC, cholangiocarcinoma
GWAS, genome wide association study
NK, natural killer
NKG2D
NKG2D, natural killer cell receptor protein G2D
PSC, primary sclerosing cholangitis
SNP, single nucleotide polymorphism
cholangiocarcinoma
genetic
risk factor
Publication Status
Published
Date Publish Online
2018-07-20