Heme Oxygenase-1 mediates neuro-protection conferred by argon in combination with hypothermia in neonatal hypoxia-ischemia brain injury
File(s)ALN-D-15-01436_R2.pdf (2.49 MB)
Accepted version
Author(s)
Type
Journal Article
Abstract
Argon–hypothermia treatment reduced both neuronal death in an in vitro neuronal culture model and brain infarct size in an in vivo rat model of neonatal asphyxia. The protective effects of argon–hypothermia involve both inhibition of apoptosis and neuroinflammation mechanisms and activation of cell survival pathways.
Date Issued
2016-04-11
Date Acceptance
2016-03-25
Citation
Anesthesiology, 2016, 125, pp.180-192
ISSN
1528-1175
Publisher
Lippincott, Williams & Wilkins
Start Page
180
End Page
192
Journal / Book Title
Anesthesiology
Volume
125
Copyright Statement
© 2016 American Society of Anesthesiologists.
Sponsor
SPort Aiding medical Research for KidS (SPARKS)
Grant Number
10IMP01
Subjects
Anesthesiology
1103 Clinical Sciences
Publication Status
Published