Information anchored reference‐based sensitivity analysis for truncated normal data with application to survival analysis
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Published version
OA Location
Author(s)
Atkinson, Andrew
Cro, Suzie
Carpenter, James R
Kenward, Michael G
Type
Journal Article
Abstract
The primary analysis of time-to-event data typically makes the censoring at random assumption, that is, that—conditional on covariates in the model—the distribution of event times is the same, whether they are observed or unobserved. In such cases, we need to explore the robustness of inference to more pragmatic assumptions about patients post-censoring in sensitivity analyses. Reference-based multiple imputation, which avoids analysts explicitly specifying the parameters of the unobserved data distribution, has proved attractive to researchers. Building on results for longitudinal continuous data, we show that inference using a Tobit regression imputation model for reference-based sensitivity analysis with right censored log normal data is information anchored, meaning the proportion of information lost due to missing data under the primary analysis is held constant across the sensitivity analyses. We illustrate our theoretical results using simulation and a clinical trial case study.
Date Issued
2021-06-17
Date Acceptance
2021-05-22
Citation
Statistica Neerlandica, 2021, 75 (4), pp.500-523
ISSN
0039-0402
Publisher
Wiley
Start Page
500
End Page
523
Journal / Book Title
Statistica Neerlandica
Volume
75
Issue
4
Copyright Statement
© 2021 The Authors. Statistica Neerlandica published by John Wiley & Sons Ltd on behalf of Netherlands Society for Statistics and Operations Research.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
https://onlinelibrary.wiley.com/doi/10.1111/stan.12250
Subjects
Science & Technology
Physical Sciences
Statistics & Probability
Mathematics
censoring not at random
informative censoring
reference-based multiple imputation
Rubin's rules
sensitivity analysis
tobit regression
truncated normal data
MULTIPLE-IMPUTATION
LONGITUDINAL TRIALS
CLINICAL-TRIALS
MISSING DATA
TIME
ASSUMPTION
INFERENCE
EFFICACY
Statistics & Probability
0104 Statistics
1403 Econometrics
Publication Status
Published online
Article Number
stan.12250
Date Publish Online
2021-05-28