Machine learning methods for locating re-entrant drivers from electrograms in a model of atrial fibrillation
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Published version
Author(s)
McGillivray, Max Falkenberg
Cheng, William
Peters, Nicholas S
Christensen, Kim
Type
Journal Article
Abstract
Mapping resolution has recently been identified as a key limitation in successfully locating the drivers of atrial fibrillation (AF). Using a simple cellular automata model of AF, we demonstrate a method by which re-entrant drivers can be located quickly and accurately using a collection of indirect electrogram measurements. The method proposed employs simple, out-of-the-box machine learning algorithms to correlate characteristic electrogram gradients with the displacement of an electrogram recording from a re-entrant driver. Such a method is less sensitive to local fluctuations in electrical activity. As a result, the method successfully locates 95.4% of drivers in tissues containing a single driver, and 95.1% (92.6%) for the first (second) driver in tissues containing two drivers of AF. Additionally, we demonstrate how the technique can be applied to tissues with an arbitrary number of drivers. In its current form, the techniques presented are not refined enough for a clinical setting. However, the methods proposed offer a promising path for future investigations aimed at improving targeted ablation for AF.
Date Issued
2018-04-18
Date Acceptance
2018-03-13
Citation
ROYAL SOCIETY OPEN SCIENCE, 2018, 5 (4)
ISSN
2054-5703
Publisher
Royal Society
Journal / Book Title
ROYAL SOCIETY OPEN SCIENCE
Volume
5
Issue
4
Copyright Statement
© 2018 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000431110100069&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
atrial fibrillation
arrythmia
cellular automata
targeted ablation
machine learning
electrograms
RANDOM FORESTS
CLASSIFICATION
TISSUE
MECHANISMS
MEDICINE
Publication Status
Published
Article Number
ARTN 172434
Date Publish Online
2018-04-18