AMP-activated protein kinase: the current landscape for drug development
File(s)
Accepted version
Author(s)
Steinberg, Gregory R
Carling, David
Type
Journal Article
Abstract
Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy homeostasis, many exciting insights into its structure, regulation and physiological roles have been revealed. While exercise, caloric restriction, metformin and many natural products increase AMPK activity and exert a multitude of health benefits, developing direct activators of AMPK to elicit beneficial effects has been challenging. However, in recent years, direct AMPK activators have been identified and tested in preclinical models, and a small number have entered clinical trials. Despite these advances, which disease(s) represent the best indications for therapeutic AMPK activation and the long-term safety of such approaches remain to be established.
Date Issued
2019-03-13
Date Acceptance
2019-03-01
Citation
Nature Reviews Drug Discovery, 2019, 18, pp.527-551
ISSN
1474-1776
Publisher
Nature Research (part of Springer Nature)
Start Page
527
End Page
551
Journal / Book Title
Nature Reviews Drug Discovery
Volume
18
Copyright Statement
© 2019 Springer Nature. The final publication is available at Springer via https://dx.doi.org/10.1038/s41573-019-0019-2
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/30867601
PII: 10.1038/s41573-019-0019-2
Subjects
Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Pharmacology & Pharmacy
FATTY-ACID OXIDATION
ACETYL-COA CARBOXYLASE
HUMAN SKELETAL-MUSCLE
ENDOPLASMIC-RETICULUM STRESS
IMPROVES GLUCOSE-HOMEOSTASIS
REDUCES HEPATIC STEATOSIS
GAMMA-SUBUNIT ISOFORMS
BEIGE ADIPOSE-TISSUE
CELL LUNG-CANCER
INSULIN-RESISTANCE
Pharmacology & Pharmacy
11 Medical and Health Sciences
06 Biological Sciences
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2019-03-13