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  5. The cost of explainability in artificial intelligence-enhanced electrocardiogram models
 
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The cost of explainability in artificial intelligence-enhanced electrocardiogram models
File(s)
revised_manuscript_v2.docx (7.37 MB)
Accepted version
Author(s)
Patlatzoglou, Konstantinos
Pastika, Libor
Barker, Joseph
Sieliwonczyk, Ewa
Khattak, Gul Rukh
more
Type
Journal Article
Abstract
Artificial intelligence-enhanced electrocardiogram (AI-ECG) models have shown outstanding performance in diagnostic and prognostic tasks, yet their black-box nature hampers clinical adoption. Meanwhile, a growing demand for explainable AI in medicine underscores the need for transparent, trust-worthy decision-making. Moving beyond post-hoc explainability techniques that have shown unreliable results, we focus on explicit representation learning using variational autoencoders (VAE), to capture inherently interpretable ECG features. While VAEs have demonstrated potential for ECG interpretability, the presumed performance-explainability trade-off remains underexplored, with many studies relying on complex, non-linear methods that obscure the morphological information of the features. In this work, we present a novel framework (VAE-SCAN) to model bi-directional, interpretable associations between ECG features and clinical factors. We also investigate how different representations affect ECG decoding performance across models with varying levels of explainability. Our findings demonstrate the cost introduced by intrinsic ECG interpretability, based on which we discuss potential implications and directions.
Date Acceptance
2025-10-27
Citation
npj Digital Medicine
URI
https://hdl.handle.net/10044/1/125370
ISSN
2398-6352
Publisher
Nature Portfolio
Journal / Book Title
npj Digital Medicine
Copyright Statement
Copyright This paper is embargoed until publication. Once published the Version of Record (VoR) will be available on immediate open access.
License URL
https://creativecommons.org/licenses/by/4.0/
Publication Status
Accepted
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