Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection
Author(s)
Type
Journal Article
Abstract
Zika virus, a mosquito-transmitted orthoflavivirus, has become a pathogen of global health concern ever since the virus caused an epidemic in Brazil in 2015 associated with approximately 700 000 laboratory-confirmed cases of congenital microcephaly. The subsequent spread of the epidemic in 2016 resulted in a wide spectrum of congenital neurological, ophthalmological, and developmental abnormalities across the Americas, Africa, and Asia. In this context, non-human primate models have become essential tools for Zika virus research to understand the pathogenesis of congenital brain injury and perinatal complications and for developing and testing medical countermeasures such as vaccines, diagnostics, and therapeutics. Fetal brain injury has been observed across various non-human primate species and is influenced by factors such as the Zika virus strain, gestational age at inoculation, and inoculation dose and route. Miscarriages are also seen as common outcomes of first trimester Zika virus infections. This Series paper reviews the diverse non-human primate models currently used for Zika virus research to mitigate the public health effects of future Zika virus epidemics.
Date Issued
2025-06-01
Date Acceptance
2025-02-01
Citation
The Lancet Microbe, 2025, 6 (6)
ISSN
2666-5247
Publisher
Elsevier
Journal / Book Title
The Lancet Microbe
Volume
6
Issue
6
Copyright Statement
© 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/40024258
PII: S2666-5247(24)00298-2
Subjects
CELLS
HEALTH
Infectious Diseases
INOCULATION
Life Sciences & Biomedicine
MACAQUES
Microbiology
OUTBREAK
PROTECTIVE EFFICACY
RHESUS
Science & Technology
SEMEN
SEROPREVALENCE
Publication Status
Published
Coverage Spatial
England
Article Number
101030
Date Publish Online
2025-02-27