Engineering extracellular vesicles with the tools of enzyme prodrug therapy
File(s)Fuhrmann_et_al-2018-Advanced_Materials.pdf (1.54 MB)
Published version
Author(s)
Type
Journal Article
Abstract
Extracellular vesicles (EVs) have been exploited as drug delivery vehicles but their therapeutic use may be limited due to off-target effects. To harness EVs’inherent properties and to couple them with site-specific drug delivery functions, EVs are incorporated into hydrogels and engineered with the tools of enzyme-prodrug therapy. Local sustained release of anti-inflammatory drugs is demonstrated in macrophage cell models.
Date Issued
2018-02-23
Date Acceptance
2017-12-21
Citation
Advanced Materials, 2018, 30 (15)
ISSN
0935-9648
Publisher
Wiley
Journal / Book Title
Advanced Materials
Volume
30
Issue
15
Copyright Statement
© 2018 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor
Medical Research Council (MRC)
Medical Research Council (MRC)
Commission of the European Communities
Engineering & Physical Science Research Council (EPSRC)
Wellcome Trust
Commission of the European Communities
Commission of the European Communities
Grant Number
MR/L012677/1
MR/K026682/1
PIIF-GA-2011-299936
EP/K020641/1
098411/Z/12/Z
ERC-2013-CoG-616417
746980
Subjects
enzyme prodrug therapy
exosomes
hydrogels
microvesicles
β-glucuronidase
02 Physical Sciences
03 Chemical Sciences
09 Engineering
Nanoscience & Nanotechnology
Publication Status
Published
Article Number
1706616